The effects of Nitric Oxide on endogenous dopamine

Imaginarium

I don't think I've seen much musing or speculation on the effects nitric oxide has on dopamine, serotonin, and related chemicals. nitric oxide has always interested & puzzled me, but now I'm seriously pondering some ponders about it.

reading material:

http://www3.interscience.wiley.com/journal/119320362/abstract
http://www.nature.com/nm/journal/v5/n12/abs/nm1299_1403.html
http://journals.lww.com/neuroreport/Abstract/1993/10000/Nitric_oxide_increases_dopamine_and_serotonin.24.aspx
http://journals.lww.com/neuroreport/Citation/1992/05000/Role_of_Nitric_Oxide_in_Nmda_Evoked_Release_of.8.aspx
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6SYR-484MBG0-24D&_user=10&_coverDate=03%2F28%2F1994&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1411834811&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=33d44a4c7445bcd3e0169b612b6c0abc
http://en.wikipedia.org/wiki/Nitric_oxide

thoughts?

Imaginarium

moar:

http://jpet.aspetjournals.org/content/284/3/1040.full

Methamphetamine (METH) is a powerful psychostimulant that produces dopaminergic neurotoxicity manifested by a decrease in the levels of dopamine, tyrosine hydroxylase activity and dopamine transporter (DAT) binding sites in the nigrostriatal system. We have recently reported that blockade of the neuronal nitric oxide synthase (nNOS) isoform by 7-nitroindazole provides protection against METH-induced neurotoxicity in Swiss Webster mice. The present study was undertaken to investigate the effect of a neurotoxic dose of METH on mutant mice lacking the nNOS gene [nNOS(−/−)] and wild-type controls. In addition, we sought to investigate the behavioral outcome of exposure to a neurotoxic dose of METH.

Imaginarium

although I suppose now that I think about it, maybe if more people were into poppers there'd be more discussion on nitric oxide