I have a little experience combining the two, I did it this 4th of July. But I did more on the order of 40mg oxycodone (I have a tolerance) and 100mg tramadol. But if you only have 5mg oxy and no tolerance, I'd take 150-200mg tram and that 5mg oxy. Tramadol lasts longer, and has a longer peak/plateau so I would take the tramadol 30-45minutes before the oxy. It should enhance the effects, no doubt.
Tramadol definitely 'enhances' the effects. I combined Tramadol and Vicodin before and felt much more of a warming effect than I would normally feel. Alone though the Tramadol barely effects me.
Tramadol, in my experience, is a very happy drug. Not a very good body high, but I'm very smiley and stuff around people. Kinda like vicodin but, again, without as big of a body high.
I vaguely remember some minor potentiation properties of tramadol, but I might be mistaken. Can anyone verify this?
IIRC tramadol has a active metabolite that is a partial agonist for the MU receptors. Though I am not sure about its affinity for the opioid recptors compared to the full agonist in question.
Basically it may be counter productive. A person that is opioid naive/not dependant it will not really matter but if you are dependant it may antagonize the full agonists if there is enough of the active metabolite and its affinity is higher.
IIRC tramadol has a active metabolite that is a partial agonist for the MU receptors. Though I am not sure about its affinity for the opioid recptors compared to the full agonist in question.
Basically it may be counter productive. A person that is opioid naive/not dependant it will not really matter but if you are dependant it may antagonize the full agonists if there is enough of the active metabolite and its affinity is higher.
This is what I was hopeing I would not have to type out. My spelling is horrible.
Btw, good to see some intellegent names from the old totse.
In the future, to other posters: if you are asking something or wondering something, pay attention to what this guy says. He knows his information.
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I vaguely remember some minor potentiation properties of tramadol, but I might be mistaken. Can anyone verify this?
Basically it may be counter productive. A person that is opioid naive/not dependant it will not really matter but if you are dependant it may antagonize the full agonists if there is enough of the active metabolite and its affinity is higher.
Feels weird man.
That is because it has an SSNRI effect.
This is what I was hopeing I would not have to type out. My spelling is horrible.
Btw, good to see some intellegent names from the old totse.
In the future, to other posters: if you are asking something or wondering something, pay attention to what this guy says. He knows his information.
Stay with me in PMs.
If you have ideas on something that needs to be done mod wise.